主讲人：文汝（乔治亚大学在读博士）

题目：Turn Up the Cellular Power Generator with Vitamin E Analogue Formulation

时间：2016-5-16（星期一）15：00-16：00

地点：武汉大学主教311教室

举办单位：皇冠新体育app水质工程系

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摘要：The down regulation of the cellular power generator, adenosine triphosphate (ATP) synthase, in cancer cells limits electron flux in the mitochondrial respiratory chain and prevents mitochondria-mediated cell death. Cancer cells up-regulate ATPase inhibitory factor 1 (IF1) and down-regulateβ-F1-ATPase of ATP synthase to enhance aerobic glycolysis for tumor growth via inhibiting total ATP synthase activity in the oxidative phosphorylation (OXPHOS) pathway. Alpha-tocopheryl succinate (α-TOS), one of the most bioactive derivatives of vitamin E, can selectively induce apoptosis in numerous cancer cells. The cancer cell selective apoptosis byα-TOS is correlated to mitochondrial destabilization, inhibition of anti-apoptotic B cell lymphoma 2 (Bcl2) and protein kinase C (PKC), caspase 3 activation, reactive oxygen species (ROS) production, mitochondrial complexes I, and II inhibition. However, there is no report elucidating the effects of α- TOS on the cellular power generator, complex V or ATP synthase. Here, we report, for the first time, cancer cell selective activation of mitochondrial ATP synthase using a suitably designed chemical formulation of α-TOS. A mitochondria targeted α-TOS nanoparticle formulation demonstrated enhanced cytotoxicity and mitochondrial activities in cancer cells by inhibiting of Bcl2 protein and activating ATP synthase. The modulation of severely compromised ATP synthase in cancer cells by the engineered formulation of α-TOS, with further development, is a promising means of transforming the acute crisis of solid cancers with down-regulatedβsubunit of ATP synthase to chronic disease.

个人简历：文汝出生于中国湖南，2010年获得武汉大学水质科学与技术专业学士学位，2012年获得新南威尔士大学硕士学位，2012至今在乔治亚大学攻读博士学位。主要研究碳纳米管的提纯和改性，论文工作重点是纳米粒子治疗癌症及高密度脂蛋白纳米粒子模仿治疗心血管疾病。